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Dr Clarence Maikuri Mang'era

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Staff Information
PERSONAL DETAILS
Designation
LECTURER
Corporate Email
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Job Category
Teaching
Division / Faculty
Faculty of Science
Directorate / Dept
DEPT. OF BIOCHEMISTRY & MOLECULAR BIO
Section
Academic
SUMMARY

Dr. Clarence Mang'era is a biochemist and molecular biologist specializing in mosquito ecology, physiology, and innovative disease vector control strategies. A key focus of his work involves investigating the effects of bioactive botanical compounds on mosquito larvae, with an emphasis on disrupting structural and hormonal pathways to create novel, environmentally friendly control methods. 

As a lecturer at Egerton University’s Department of Biochemistry and Molecular Biology, Dr. Mang’era teaches Biochemistry, Cell and Molecular Biology, Bioinformatics, and Entomology while mentoring future scientists in interdisciplinary research. He heads the Mosquito Ecology and Control Laboratory (MECL) at Egerton University. He actively engages in the global scientific community as an Executive Council Member of the Federation of African Societies of Biochemistry and Molecular Biology (FASBMB) and Kenya’s representative at the International Union of Biochemistry and Molecular Biology (IUBMB), fostering collaborations between researchers and policymakers. Additionally, he contributes to scientific peer review as an academic editor for PLoS Neglected Tropical Diseases and a reviewer for journals such as the Journal of Insect Science.

Dr. Mang'era’s postdoctoral research focuses on developing botanical insect growth regulators (IGRs) to disrupt the development of Anopheles gambiae mosquito larvae. His work at the MECL involves:

  • Formulating potent botanical IGR blends with growth-disrupting properties.
  • Investigating morphogenic and developmental abnormalities in mosquito larvae exposed to phytochemical extracts.
  • Establishing temporal toxicity profiles of selected plant-derived compounds.

By combining biochemistry, entomology, and translational research, Dr. Mang'era aims to contribute to safer, more effective vector control methods that reduce the burden of mosquito-borne diseases in endemic regions.

ORCID
https://orcid.org/0000-0002-3972-2284
LinkedIn
https://www.linkedin.com/in/clarencemangera/
Researchgate
https://www.researchgate.net/profile/Clarence-Mangera
Google Scholar
https://scholar.google.com/citations?user=S940xt0AAAAJ&hl=en
ACADEMIC QUALIFICATIONS
  1. Ph.D. Biochemistry - Kenyatta University, Kenya
  2. MSc Biochemistry - Egerton University, Kenya
  3. BSc Biomedical Science and Technology - Egerton University, Kenya

 

FIELDS OF SPECIALIZATION
  • Molecular Entomology (Disease vector control)
  • Molecular Parasitology
  • Integrated vector management (IVM) in mosquito control
  • Bioinformatics (NGS data processing, Genome annotation)
  • Phytochemistry
PROFESSIONAL QUALIFICATIONS

Genome annotation (VectorBase)

Reviewer for Scientific Journals (Publons):

  • International journal of tropical insect science - Springer Nature
  • Journal of Herbal Medicine - Elsevier
  • Journal of Insect Science - Oxford University Press
  • PLoS Neglected Tropical Diseases - PLOS (Academic Editor)

Laboratory Biosafety and Biosecurity

One Health

WORK EXPERIENCE
  • July 2021 - Present Lecturer, Department of Biochemistry and Molecular Biology, Egerton University
  • July 2013 - July 2021 Assistant Lecturer, Department of Biochemistry and Molecular Biology, Egerton University
  • March 2014 – Aug 2017 PhD internship (DRIP) - The International Centre of Insect Physiology and Ecology (icipe)
  • Sep 2011- Feb 2013 Graduate Assistant – Egerton University
  • Sep 2010 – May 2013 Graduate Assistant – Technical University of Kenya
  • May 2009 – Aug 2010 Student Research Assistant – Kenya Medical Research Institute

 

KEY PROJECTS
  • June 2013 – Feb  2016 : Toxicity of Curry tree Phytochemical(s) to Anopheles gambiae Malaria Vector Donor: Grand Challenges Canada; Total Funding: CAD 100,000 for 18 months. Partners: ICIPE - Kenya, Egerton University-Kenya, Kenyatta University - Kenya, (PI-Kenya: Mr. Mang’era Clarence)http://www.grandchallenges.ca/grantee-stars/0269-01/
RESEARCH INTERESTS

Biology of disease vectors (Mosquito, Tsetse)

Neglected Tropical Diseases

Computational and Cell Biology

Phytochemistry

Natural Products in Vector Control

 

LIST OF PUBLICATIONS
    1. Ogolla, O., Mugunieri, L. G., Mdachi, R. E., Wanjala, K. B., Mireji, P. O., Mang’era, C. M., Kurgat, R. K., Alusi,

    P. M., Malimo, K. N., & Chemuliti, J. K. (2024). Quality, supply chain, and use of Trypanocidal drugs among camel keepers in north-eastern Kenya: A cross-sectional study. Veterinary Parasitology Regional Studies  and Reports, 101095. https://doi.org/10.1016/j.vprsr.2024.101095

  2. Ogolla KO, Onyango T, Bwana BK, Otiende MY, Mang’era CM, Ochieng B, Omolo MO, Mugambi JM, Hassanali A, Omondi P and Mireji PO (2023) Bloodmeal host identities among sympatric Glossina austeni and Glossina pallidipes tsetse flies in Shimba Hills National Reserve, Kwale, Kenya. Front. Trop. Dis 4:1145993. doi:10.3389/fitd.2023.1145993

  3. Mireji PO, Mang’era CM, Bwana BK and Hassanali A (2022) Perspectives on Odor-Based Control of Tsetse Flies in Africa. Front. Physiol. 13:831618. doi: 10.3389/fphys.2022.831618

  4. Mutuku CN; Bateta R;  Rono MK;  Njunge JM;  Awuoche EO;  Ndung'u K; Mang'era CM;  Akoth MO;  Adung'a VO;  Ondigo BN;  Mireji PO. Physiological and proteomic profiles of Trypanosoma brucei rhodesiense parasite isolated from suramin responsive and non-responsive HAT patients in Busoga, Uganda. Int J Parasitol Drugs Drug Resist. 2021;15:57-67; https://doi.org/10.1016/j.ijpddr.2021.02.001.

  5. Mang'era, CM.;  Khamis, FM.;  Awuoche, EO.;  Hassanali, A;  Ombura, FLO;  Mireji, PO. Transcriptomic response of Anopheles gambiae sensu stricto mosquito larvae to Curry tree (Murraya koenigii) phytochemicals. Parasit Vectors. 2021; Jan 2;14(1):1. https://doi.org/10.1186/S13071-020-04505-4

  6. Kabaka JM, Wachira BM, Mang’era CM, Rono MK, Hassanali A, Okoth SO, et al. Expansions of chemosensory gene orthologs among selected tsetse fly species and their expressions in glossina morsitans morsitans tsetse fly. PLoS Negl Trop Dis. 2020;14:1–23. https://doi.org/10.1371/journal.pntd.0008341 

  7. Mang’era CM, Hassanali A, Khamis FM, Rono MK, Lwande W, Mbogo C, Mireji PO. 2018. Growth-disrupting Murraya koenigii leaf extracts on Anopheles gambiae larvae and identification of associated candidate bioactive constituents. Acta Trop. 190:304–11. https://doi.org/10.1016/j.actatropica.2018.12.009

  8. Mang’era, C.M., Mbai F.N., Omedo I.A., Omar S.A., 2012. Changes in genotypes of Plasmodium falciparum human malaria parasite following withdrawal of chloroquine in Tiwi, Kenya. Acta Trop. 123, 202-207.https://doi.org/10.1016/j.actatropica.2012.05.007

  9. Shaviya, N., Mang’era, C.M., Makokha, F.W., Kimani, F.T., Ongus, J.R. 2012 Expansion of the wildtype pfcrt 76K allele in Plasmodium falciparum populations in Mbita, Kenya. African Journal of Health Sciences 22, 176-187.

  10. Shaviya, N., Zablon, J.O., Mang’era, C.M., Makokha, F.W., Wamalwa, R.W., Sowayi, G.A. 2014. Genotyping for point mutations in selected codons of pfcrt and pfmdr-1 genes of Plasmodium falciparum among patients with uncomplicated malaria in Mbita district Kenya. Journal of Natural Sciences Research 4, 114-123.

CONFERENCES & INVITED PRESENTATIONS

Mang'era C.M. (2021, July 16) Induction of Molecular and Physiological Responses in Malaria Vectors to Curry Tree Leaf Phytochemicals. Seminar presented at Postgraduates conference, Kenyatta University.

TEACHING AREAS
  • Biomedical Sciences and Technology
  • Biochemistry
  • Research Methods
POSTGRADUATE SUPERVISION
MASTERS LEVEL :

Jackline Kirui - Ongoing - MSc Biochemistry - Evaluation of Anti-SARS-CoV-2 Phytochemical Activity of Selected Medicinal Plants from Baringo County, Kenya

Alex Muriithi - Ongoing - MSc Biochemistry - Identification of Novel Antibacterial Endophyte-Derived Compounds from Rotheca Myricoides Targeting ESKAPE Pathogens

Esther Nonaishi - Ongoing - MSc Biochemistry - Mosquito Larvae Growth Regulation Control Intervention in Western Kenya

Prexiedes Waswa - Ongoing - MSc Biochemistry - Effects Of Entomopathogenic Fungi, Metarhizium Anisopliae on Immunological Responses and Gut Microbiome Of Ticks

 

OTHER SOCIETIES
  1. Member - American Society of Tropical Medicine and Hygiene (ASMTH)
  2. Member - The American Committee of Medical Entomology (ACME)
  3. Council Member - Federation of African Societies of Biochemistry and Molecular Biology (FASBMB) https://fasbmb.org/executive-committee
  4. Organizing committee member - Biochemistry and Biotechnology Professionals Society of Kenya (BBPSK) https://bbpsk.or.ke/
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